Hippocampal sclerosis in epilepsy: a neuropathology review

M Thom - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?

G Curia, C Lucchi, J Vinet, F Gualtieri… - Current medicinal …, 2014 - ingentaconnect.com
Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

Эпилепсия у детей и взрослых женщин и мужчин

ВА Карлов - 2019 - elibrary.ru
В руководстве представлены результаты 60-летней работы автора в области детской
и взрослой неврологии и эпилептологии. Впервые эпилептология представлена в …

[HTML][HTML] Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

C Lentini, M d'Orange, N Marichal, MM Trottmann… - Cell stem cell, 2021 - cell.com
Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges

TJ Ellender, JV Raimondo, A Irkle… - Journal of …, 2014 - Soc Neuroscience
Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within
brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer …

Interictal to ictal transition in human temporal lobe epilepsy: insights from a computational model of intracerebral EEG

F Wendling, A Hernandez, JJ Bellanger… - Journal of Clinical …, 2005 - journals.lww.com
In human partial epilepsies and in experimental models of chronic and/or acute epilepsy, the
role of inhibition and the relationship between the inhibition and excitation and …

Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus

A Ludányi, L Erőss, S Czirják, J Vajda… - Journal of …, 2008 - Soc Neuroscience
Endocannabinoid signaling is a key regulator of synaptic neurotransmission throughout the
brain. Compelling evidence shows that its perturbation leads to development of epileptic …

Selective activation of parvalbumin-or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

L Yekhlef, GL Breschi, L Lagostena… - Journal of …, 2015 - journals.physiology.org
GABAergic interneurons are thought to play a critical role in eliciting interictal spikes (IICs)
and triggering ictal discharges in temporal lobe epilepsy, yet the contribution of different …

Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Z Maglóczky, TF Freund - Trends in neurosciences, 2005 - cell.com
This review focuses on the epileptic human temporal lobe, primarily on recent findings
related to changes in hippocampal GABAergic interneuron circuits that have a central role in …

Parvalbumin role in epilepsy and psychiatric comorbidities: from mechanism to intervention

LD Godoy, T Prizon, MT Rossignoli, JP Leite… - Frontiers in Integrative …, 2022 - frontiersin.org
Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …