Is the HPA axis as target for depression outdated, or is there a new hope?
A Menke - Frontiers in psychiatry, 2019 - frontiersin.org
Major depressive disorder (MDD) is a very common stress-related mental disorder that
carries a huge burden for affected patients and the society. It is associated with a high …
carries a huge burden for affected patients and the society. It is associated with a high …
Cortisol and cardiometabolic disease: a target for advancing health equity
Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact
the development of, and outcomes in, cardiovascular disease (CVD) through allostatic load …
the development of, and outcomes in, cardiovascular disease (CVD) through allostatic load …
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
Childhood trauma, the stress response and metabolic syndrome: a focus on DNA methylation
Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …
mental disorders. However, the potential of adverse early experiences to exert chronic and …
[HTML][HTML] Focus on FKBP51: A molecular link between stress and metabolic disorders
Abstract Background Obesity, Type 2 diabetes (T2D) as well as stress-related disorders are
rising public health threats and major burdens for modern society. Chronic stress and …
rising public health threats and major burdens for modern society. Chronic stress and …
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
The metabolic-epigenetic nexus in type 2 diabetes mellitus
The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …
The promise of CRISPR/Cas9 technology in diabetes mellitus therapy: How gene editing is revolutionizing diabetes research and treatment
Y Cheng, H Wang, M Li - Journal of Diabetes and its Complications, 2023 - Elsevier
Diabetes mellitus is a metabolic disease, characterized by chronic hyperglycemia caused by
an abnormality in insulin secretion or action. Millions of people across the world are affected …
an abnormality in insulin secretion or action. Millions of people across the world are affected …
Analysis of the selective antagonist SAFit2 as a chemical probe for the FK506-binding protein 51
V Buffa, FH Knaup, T Heymann… - ACS Pharmacology & …, 2023 - ACS Publications
The FK506-binding protein 51 (FKBP51) has emerged as an important regulator of the
mammalian stress response and is involved in persistent pain states and metabolic …
mammalian stress response and is involved in persistent pain states and metabolic …
Comorbidities in mild autonomous cortisol secretion–a clinical review of literature
A Czapla-Iskrzycka… - Experimental and …, 2022 - thieme-connect.com
Mild autonomous cortisol secretion (mACS) is a state of cortisol excess usually associated
with existence of adrenal incidentaloma. Because of the lack of symptoms of the disease, the …
with existence of adrenal incidentaloma. Because of the lack of symptoms of the disease, the …