Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

Extracellular vesicles (EVs) that are derived from mesenchymal stromal cells (MSCs) have
been shown to reprogram injured cells by activating regenerative processes. We herein …

The pathophysiology of diabetic nephropathy (DN), one of the most serious complications in
diabetic patients and the leading cause of end-stage renal disease worldwide, is complex …

Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

Epithelial-to-mesenchymal transition (EMT) plays an important role in renal interstitial
fibrosis (RIF) with diabetic nephropathy (DN). Smad7 (a inhibitory smad), a downstream …

Stem and progenitor cells are characterized by their ability to self-renew and produce
differentiated progeny. A fine balance between these processes is achieved through …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important
cause of end-stage renal failure is characterized by changes in the molecular and cellular …

Diabetic nephropathy (DN) is regarded as the leading cause of end-stage renal disease
worldwide and lacks novel therapeutic targets. To screen and verify special biomarkers for …