In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an
essential role for nutrition and gut barrier function. However, research on farm animal …

Animal organoid models derived from farm and companion animals have great potential to
contribute to human health as a One Health initiative, which recognize a close inter …

Abstract Mammalian three-dimensional (3D) enteroids mirror in vivo intestinal organisation
and are powerful tools to investigate intestinal cell biology and host–pathogen interactions …

Gastrointestinal (GI) infections in sheep have significant implications for animal health,
welfare and productivity, as well as being a source of zoonotic pathogens. Interactions …

The small intestinal mucosa constitutes a physical barrier separating the gut lumen from
sterile internal tissues. Junctional complexes between cells regulate transport across the …

Recent progress in bovine intestinal organoid research has expanded opportunities for
creating improved in vitro models to study intestinal physiology and pathology. However, the …

Abstract Three-dimensional (3D) colon organoids, termed “colonoids”, derived from adult
stem cells represent a powerful tool in in vitro pharmaceutical and toxicological research …

Species A rotavirus (RVA) vaccines based on live attenuated viruses are used worldwide in
humans. The recent establishment of a reverse genetics system for rotoviruses (RVs) has …

Preclinical biomedical research is limited by the predictiveness of in vivo and in vitro models.
While in vivo models offer the most complex system for experimentation, they are also …

Salmonella enterica serovar Dublin (S. Dublin) is an important enteric pathogen affecting
cattle and poses increasing public health risks. Understanding the pathophysiology and host …