Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

Limited endoproteolysis of inactive precursor proteins at sites marked by paired or multiple
basic amino acids is a widespread process by which biologically active peptides and …

Many viruses have membrane glycoproteins that are activated at cleavage sites containing
multiple arginine and lysine residues by cellular proteases so far not identified. The …

Previous work demonstrated that human furin is a predominantly Golgi membrane-localized
endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys …

Proproteins and prohormones are the fundamental units from which bioactive proteins and
peptides as well as neuropeptides are derived by limited proteolysis within the secretory …

Insulin plays a central role in the regulation of human metabolism. The hormone is a 51-
residue anabolic protein that is secreted by the β-cells in the Islets of Langerhans …

Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide
hormones within its structure. These peptide hormones can be generated by cleavage of …

A recombinant vaccinia virus vector was used to coexpress the two candidate mouse
prohormone convertases, PC1 and PC2, together with mouse proopiomelanocortin (POMC) …

Many peptide hormones are produced from larger precursors by endoproteolysis at pairs of
basic amino acids (eg Lys-Arg and Arg-Arg) within the regulated secretory pathway in …

Rehfeld, Jens F. The New Biology of Gastrointestinal Hormones. Physiol. Rev. 78: 1087–
1108, 1998.—The classic concept of gastrointestinal endocrinology is that of a few peptides …