Carboxylic ester hydrolases in bacteria: Active site, structure, function and application
C Oh, TD Kim, KK Kim - Crystals, 2019 - mdpi.com
Carboxylic ester hydrolases (CEHs), which catalyze the hydrolysis of carboxylic esters to
produce alcohol and acid, are identified in three domains of life. In the Protein Data Bank …
produce alcohol and acid, are identified in three domains of life. In the Protein Data Bank …
Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential
Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the
maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from …
maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from …
Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase
Bacterial peptidyl-tRNA hydrolase (Pth; EC 3.1. 1.29) hydrolyzes the peptidyl-tRNAs
accumulated in the cytoplasm and thereby prevents cell death by alleviating tRNA …
accumulated in the cytoplasm and thereby prevents cell death by alleviating tRNA …
Structural characterization of peptidyl-tRNA hydrolase from Mycobacterium smegmatis by NMR spectroscopy
Background Accumulation of toxic peptidyl-tRNAs in the bacterial cytoplasm is averted by
the action of peptidyl-tRNA hydrolase (Pth), which cleaves peptidyl-tRNA into free tRNA and …
the action of peptidyl-tRNA hydrolase (Pth), which cleaves peptidyl-tRNA into free tRNA and …
Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies
All mRNAs cannot be translated into full-length proteins due to ribosome-stalling that leads
to release of peptidyl-tRNA which can be lethal for bacterial survival. The enzyme peptidyl …
to release of peptidyl-tRNA which can be lethal for bacterial survival. The enzyme peptidyl …
Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 Å resolution
F Zhang, Y Song, L Niu, M Teng… - Acta Biochimica et …, 2015 - academic.oup.com
Peptidyl-tRNA hydrolase (Pth) catalyzes the release of tRNA to relieve peptidyl-tRNA
accumulation. Because Pth activity is essential for the viability of bacteria, Pth is regarded as …
accumulation. Because Pth activity is essential for the viability of bacteria, Pth is regarded as …
Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and
tRNA components. Pth from Acinetobacter baumannii (Ab Pth) was cloned, expressed …
tRNA components. Pth from Acinetobacter baumannii (Ab Pth) was cloned, expressed …
Structural and functional characterization of peptidyl-tRNA hydrolase from Klebsiella pneumoniae
Klebsiella pneumoniae is a member of the ESKAPE panel of pathogens that are top priority
to tackle AMR. Bacterial peptidyl tRNA hydrolase (Pth), an essential, ubiquitous enzyme …
to tackle AMR. Bacterial peptidyl tRNA hydrolase (Pth), an essential, ubiquitous enzyme …
Isolation and Analysis of Salt Response of Lactobacillus plantarum FS5-5 from Dajiang
X Song, Q Wang, X Xu, J Lin, X Wang, Y Xue… - Indian journal of …, 2016 - Springer
From 15 samples of dajiang collected in northeast of China, three salt resistant lactic acid
bacteria were isolated and identified as Lactobacillus plantarum through physiological …
bacteria were isolated and identified as Lactobacillus plantarum through physiological …
High‐resolution crystal structure of peptidyl‐tRNA hydrolase from Thermus thermophilus
A Matsumoto, Y Uehara, Y Shimizu… - Proteins: Structure …, 2019 - Wiley Online Library
Peptidyl‐tRNA hydrolase (Pth) cleaves the ester bond between the peptide and the tRNA of
peptidyl‐tRNA molecules, which are the products of defective translation, to recycle the …
peptidyl‐tRNA molecules, which are the products of defective translation, to recycle the …