The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we
studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target …

Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs
but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report …

The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

Antibody secreting cells (ASCs) are terminally differentiated cells of the humoral immune
response and must adapt morphologically, transcriptionally, and metabolically to maintain …

Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian
cells by increasing the number of protein isoforms that can be generated from one gene …

The latest advances in next‐generation sequencing studies and transcriptomic profiling over
the past decade have highlighted a surprising frequency of genes regulated by RNA …