Clinical protein mass spectrometry

A Scherl - Methods, 2015 - Elsevier
Quantitative protein analysis is routinely performed in clinical chemistry laboratories for
diagnosis, therapeutic monitoring, and prognosis. Today, protein assays are mostly …

Nanomaterials for fluorescent detection of hemoglobin

Y Guo, Y Tang, Y Tan, Y Li, Y Xiang - Critical Reviews in Analytical …, 2024 - Taylor & Francis
Hemoglobin plays a vital role in a series of biological activities. Abnormal levels of
hemoglobin in blood are associated with many clinical diseases. Therefore, development of …

Capillary zone electrophoresis-top-down tandem mass spectrometry for in-depth characterization of hemoglobin proteoforms in clinical and veterinary samples

A Stolz, Y Hedeland, L Salzer, J Römer… - Analytical …, 2020 - ACS Publications
Hemoglobin (Hb) constitutes an important protein in clinical diagnostics—both in humans
and animals. Among the high number of sequence variants, some can cause severe …

Smart proteolysis samplers for pre‐lab bottom‐up protein analysis–performance of on‐paper digestion compared to conventional digestion

MT Nguyen, TG Halvorsen, B Thiede… - Separation Science …, 2022 - Wiley Online Library
Here the relation between digestion of proteins by trypsin covalently bound to paper and
trypsin in‐solution is investigated. The trypsin acting on paper is covalently bound. A trypsin …

Optimization and Identification of Single Mutation in Hemoglobin Variants with 2, 2, 2 Trifluoroethanol Modified Digestion Method and Nano− LC Coupled MALDI MS …

P Dasauni, N Singh, V Chhabra, M Mahapatra… - Molecules, 2022 - mdpi.com
Background: Hemoglobin (Hb) variants arise due to point mutations in globin chains and
their pathological treatments rely heavily on the identification of the nature and location of …

Identification of hemoglobin variants by top-down mass spectrometry using selected diagnostic product ions

D Coelho Graça, R Hartmer, W Jabs, P Beris… - Analytical and …, 2015 - Springer
Hemoglobin disorder diagnosis is a complex procedure combining several analytical steps.
Due to the lack of specificity of the currently used protein analysis methods, the identification …

Development of microwave-assisted acid hydrolysis of proteins using a commercial microwave reactor and its combination with LC–MS for protein full-sequence …

L Chen, N Wang, L Li - Talanta, 2014 - Elsevier
Microwave-assisted acid hydrolysis (MAAH) can be used to degrade a protein non-
specifically into many peptides with overlapping sequences which can be identified by mass …

Surface analysis for proteomics via liquid extraction surface analysis mass spectrometry and liquid chromatography mass spectrometry

NJ Martin - 2016 - etheses.bham.ac.uk
Liquid extraction surface analysis (LESA) is an ambient ionisation technique which allows
direct analysis of surfaces coupled with mass spectrometry. LESA mass spectrometry has …

[PDF][PDF] Федеральное государственное бюджетное образовательное учреждение высшего образования «ЮЖНО-УРАЛЬСКИЙ ГОСУДАРСТВЕННЫЙ …

Н Глухих, Л Шибакова - Кафедра, 2019 - cspu.ru
Федеральное государственное бюджетное образовательное учреждение в Page 1
Кафедра русского языка и методики обучения русскому языку Глухих Наталья …