Polymorphism in crystals is known since 1822 and the credit goes to Mitscherlich who
realized the existence of different crystal structures of the same compound while working …

The past decade has witnessed remarkable progress in cocrystal research, by virtue of the
desires to address problematic properties of drugs. Notwithstanding the rapid advancements …

Herein is presented a rare example of salt/cocrystal polymorphism involving the adduct
between ethionamide (ETH) and salicylic acid (SAL). Both the salt and cocrystal forms have …

In this research work, bicomponent structures of salicylic acid were synthesized by reflux
condition. The cofomers used were 1-10-phenanthroline, 5-chlorobenzotiazole, and 2 …

Ketoprofen–l-lysine salt (KLS) is a widely used nonsteroidal anti-inflammatory drug. Here,
we studied deeply the solid-state characteristics of KLS to possibly identify new polymorphic …

Many efforts have been recently devoted to the design and investigation of multicomponent
pharmaceutical solids, such as salts and cocrystals. The experimental distinction between …

The 1: 1 caffeine (CAF) and 3-nitrobenzoic acid (NBA) cocrystal (CAF: NBA) displays
polymorphism. Each polymorph shares the same docking synthon that connects individual …

Sulfamethizole (SMZ) is an antibiotic drug with good solubility but short in vivo half-life. Thus,
reducing the dissolution rate is expected to improve bioavailability and therapeutic activity …

Both sorafenib (SOR) and regorafenib (REG), which are structurally similar, can form drug–
drug cocrystals with 5-fluorouracil (FU). However, while SOR-FU could be prepared easily …

Desired goals of crystal synthesis include high crystal quality (eg, pure solid forms and
uniform size distribution) and high process efficiency and reproducibility. A simple …