As a detoxification and metabolism organ, the liver plays a vital role in human health.
However, an excessive consumption of drugs and toxins, exposure to pathogenic viruses …

Background: Hypoxia and anoxia are dangerous and sometimes irreversible complications
in the central nervous system (CNS), which in some cases lead to death. Objective: The aim …

Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins
inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear …

We have previously reported that the n-3 polyunsaturated fatty acid eicosapentaenoic acid
(EPA) inhibited the abnormal gap junctional intercellular communication (GJIC) induced by …

Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of
endothelium are frequently observed in patients with diabetes and cardiovascular disease …

Icariin is a flavonoid isolated from Epimedium and is considered to be the major
pharmacological active component of Epimedii Herba. In the present investigation, we …

Two trisaccharide steroidal saponins, dioscin (1) and Xiebai saponin I (2) with various
bioactivities, were efficiently synthesized using the newly developed glycosyl N-phenyl …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive
loss of neurons and production of β-amyloid proteins (Aβ). Hyperphosphorylation of tau …

Icariin, icaritin and desmethylicaritin are constituents of Epimedium with a similar structure to
genistein and daidzein. Using the modified MCF-7 cell proliferation assay (E-SCREEN …

Myocardial ischemia/reperfusion (I/R) injury is a clinically severe complication, which can
cause high rates of disability and mortality particularly in patients with myocardial infarction …