Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

H Döhner, E Estey, D Grimwade… - Blood, The Journal …, 2017 - ashpublications.org
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) in adults, published in 2010, has found …

Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

L Xuan, Q Liu - Journal of Hematology & Oncology, 2021 - Springer
Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML)
undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging …

A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients

B Oran, M de Lima, G Garcia-Manero, PF Thall… - Blood …, 2020 - ashpublications.org
This study investigated the efficacy and safety of azacitidine maintenance in the
posttransplant setting based on the encouraging phase 1/2 reports for azacitidine …

Eprenetapopt Plus Azacitidine After Allogeneic Hematopoietic Stem-Cell Transplantation for TP53-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes

A Mishra, R Tamari, AE DeZern, MT Byrne… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Outcomes are poor in TP53-mutant (m TP53) acute myeloid leukemia (AML) and
myelodysplastic syndromes (MDS), even after allogeneic hematopoietic stem-cell transplant …

Effect of rhG-CSF combined with decitabine prophylaxis on relapse of patients with high-risk MRD-negative AML after HSCT: an open-label, multicenter, randomized …

L Gao, Y Zhang, S Wang, P Kong, Y Su, J Hu… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-
cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim of …

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: prevention, detection, and treatment

C Rautenberg, U Germing, R Haas, G Kobbe… - International journal of …, 2019 - mdpi.com
Acute myeloid leukemia (AML) is a phenotypically and prognostically heterogeneous
hematopoietic stem cell disease that may be cured in eligible patients with intensive …

Low‐dose decitabine plus venetoclax is safe and effective as post‐transplant maintenance therapy for high‐risk acute myeloid leukemia and myelodysplastic …

Y Wei, X Xiong, X Li, W Lu, X He, X Jin, R Sun… - Cancer …, 2021 - Wiley Online Library
Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are usually associated
with poor outcomes, especially in high‐risk AML/MDS. Allogeneic hematopoietic stem cell …

Maintenance therapy in AML: the past, the present and the future

M Molica, M Breccia, R Foa, E Jabbour… - American journal of …, 2019 - Wiley Online Library
Curative treatment in acute myeloid leukemia (AML) depends on successful induction
therapy to achieve a complete remission (CR), and subsequent post‐remission therapy to …

Prospective phase II study of prophylactic low-dose azacitidine and donor lymphocyte infusions following allogeneic hematopoietic stem cell transplantation for high …

T Guillaume, F Malard, L Magro, M Labopin… - Bone marrow …, 2019 - nature.com
Thirty patients, with high-risk acute myeloid leukemia (AML, n= 20) or myelodysplastic
syndrome (MDS, n= 10), were enrolled in a phase II trial entailing prophylactic post …

Current status and new treatment approaches in TP53 mutated AML

AM Hunter, DA Sallman - Best practice & research Clinical haematology, 2019 - Elsevier
Mutations in the essential tumor suppressor gene, TP53, are observed in only 5–10% of
acute myeloid leukemia (AML) cases, but are highly associated with therapy-related AML …