One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Neurodegenerative disorders involve the slow and gradual degeneration of axons and
neurons in the central nervous system (CNS), resulting in abnormalities in cellular function …

Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …

Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene
transfer. AAV serotype 2 (AAV2) is commonly used to deliver transgenes to retinal ganglion …

Abstract Intracellular calcium (Ca2+) and phosphoinositides (PIPs) are crucial for regulating
cellular activities such as metabolism and cell survival. Cells maintain precise intracellular …

The lack of neuroprotective treatments for retinal ganglion cells (RGCs) and optic nerve (ON)
is a central challenge for glaucoma management. Emerging evidence suggests that redox …