The cells in the human body are continuously challenged by a variety of genotoxic attacks.
Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can …

Abstract p53 mutants that lack DNA-binding activities, and therefore, transcriptional
activities, are among the most common mutations in human cancer. Recently, a new role for …

The cardiotoxic effects of doxorubicin, a potent chemotherapeutic agent, have been linked to
DNA damage, oxidative mitochondrial damage, and nuclear translocation of p53, but the …

The tumour suppressor p53 is a central player in cellular DNA damage responses. P53 is
upregulated and activated by genotoxic stress and induces a transcriptional programme with …

The key role of p53 as a tumor suppressor became clear when it was realized that this gene
is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to …

Convergent studies demonstrated that p53 regulates homologous recombination (HR)
independently of its classic tumour-suppressor functions in transcriptionally transactivating …

In mammalian cells, DNA double-strand breaks (DSBs) are repaired by three pathways,
nonhomologous end-joining (NHEJ), gene conversion (GC) and single-strand annealing …

Abstract p53 is a tumor suppressor protein that prevents oncogenic transformation and
maintains genomic stability by blocking proliferation of cells harboring unrepaired or …

The p53 tumor suppressor protein is a key mediator of an ATM-dependent DNA damage
response cascade following cellular exposure to ionizing radiation. The p53-family …

Trp53 is arguably the most critical tumour suppressor gene product that inhibits malignant
transformation. Besides mutations that inactivate Trp53 functions, genetic polymorphisms …