An overview on the therapeutics of neglected infectious diseases—Leishmaniasis and Chagas diseases

K Chanda - Frontiers in Chemistry, 2021 - frontiersin.org
Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

The many faces of the adamantyl group in drug design

J Liu, D Obando, V Liao, T Lifa, R Codd - European journal of medicinal …, 2011 - Elsevier
Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

Novel heteroaryl selenocyanates and diselenides as potent antileishmanial agents

Y Baquedano, V Alcolea, MÁ Toro… - Antimicrobial agents …, 2016 - Am Soc Microbiol
ABSTRACT A series of new selenocyanates and diselenides bearing interesting bioactive
scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was …

α-Aminophosphonates as novel anti-leishmanial chemotypes: synthesis, biological evaluation, and CoMFA studies

S Bhagat, P Shah, SK Garg, S Mishra, PK Kaur… - …, 2014 - pubs.rsc.org
A series of twenty six structurally diverse α-aminophosphonates have been synthesized and
evaluated for in vitro anti-leishmanial activity and cytotoxicity using the MTT assay. Among …

Benzimidazole derivatives endowed with potent antileishmanial activity

M Tonelli, E Gabriele, F Piazza, N Basilico… - Journal of Enzyme …, 2018 - Taylor & Francis
Two sets of benzimidazole derivatives were synthesised and tested in vitro for activity
against promastigotes of Leishmania tropica and L. infantum. Most of the tested compounds …

Aurones: a promising heterocyclic scaffold for the development of potent antileishmanial agents

M Roussaki, S Costa Lima, AM Kypreou… - … journal of medicinal …, 2012 - Wiley Online Library
A series of (Z)‐2‐benzylidenebenzofuran‐3‐(2H)‐ones (aurones) bearing a variety of
substituents on rings A and B were synthesized and evaluated for their antiparasitic activity …

Effect of alkylphospholipids on Candida albicans biofilm formation and maturation

TVM Vila, K Ishida, W de Souza… - Journal of …, 2013 - academic.oup.com
Objectives The aim of this study was to evaluate miltefosine and four synthetic compounds
(TCAN26, TC19, TC106 and TC117) for their in vitro inhibitory activity against Candida …

Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines

VS Gontijo, PF Espuri, RB Alves… - European Journal of …, 2015 - Elsevier
A series of 16 simple long-chain alkyltriazoles and two novel alkylphosphocholine
derivatives containing an azide moiety were evaluated in vitro for their leishmanicidal activity …

Synthesis, crystallographic study, molecular docking, ADMET, DFT and biological evaluation of new series of aurone derivatives as anti-leishmanial agents

SA Nabi, F Ramzan, MS Lone, MA Beg, A Hamid… - Journal of Molecular …, 2022 - Elsevier
A new series of aurone derivatives (4a-l) was synthesized and their structures were
established on the basis of IR, NMR, mass spectra and elemental analysis. In addition, the …

New amides containing selenium as potent leishmanicidal agents targeting trypanothione reductase

M Etxebeste-Mitxeltorena, D Plano… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Two new series of 28 selenocyanate and diselenide derivatives containing amide moieties
were designed, synthesized, and evaluated for their leishmanicidal activity against …