The construction of transgenic and gene knockout/knockin mouse models of human disease
The genetic and physiological similarities between mice and humans have focused
considerable attention on rodents as potential models of human health and disease …
considerable attention on rodents as potential models of human health and disease …
Coup d'Etat: an orphan takes control
FJ Lin, J Qin, K Tang, SY Tsai, MJ Tsai - Endocrine reviews, 2011 - academic.oup.com
Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the
steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the …
steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the …
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
Y Tian, Y Liu, T Wang, N Zhou, J Kong… - Science translational …, 2015 - science.org
In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after
injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the …
injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the …
[HTML][HTML] Opposing functions of BRD4 isoforms in breast cancer
Summary Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the
phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic …
phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic …
[HTML][HTML] Atrial identity is determined by a COUP-TFII regulatory network
S Wu, CM Cheng, RB Lanz, T Wang, JL Respress… - Developmental cell, 2013 - cell.com
Atria and ventricles exhibit distinct molecular profiles that produce structural and functional
differences between the two cardiac compartments. However, the factors that determine …
differences between the two cardiac compartments. However, the factors that determine …
Estrogen receptor–α in medial amygdala neurons regulates body weight
Estrogen receptor–α (ERα) activity in the brain prevents obesity in both males and females.
However, the ERα-expressing neural populations that regulate body weight remain to be …
However, the ERα-expressing neural populations that regulate body weight remain to be …
Androgen deprivation–induced NCoA2 promotes metastatic and castration-resistant prostate cancer
A major clinical hurdle for the management of advanced prostate cancer (PCa) in patients is
the resistance of tumors to androgen deprivation therapy (ADT) and their subsequent …
the resistance of tumors to androgen deprivation therapy (ADT) and their subsequent …
Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment
The precise timing of progesterone signaling through its cognate receptor, the progesterone
receptor (PGR), is critical for the establishment and maintenance of pregnancy. Loss of PGR …
receptor (PGR), is critical for the establishment and maintenance of pregnancy. Loss of PGR …
Neuron-astroglia cell fate decision in the adult mouse hippocampal neurogenic niche is cell-intrinsically controlled by COUP-TFI in vivo
In the dentate gyrus (DG) of the mouse hippocampus, neurogenesis and astrogliogenesis
persist throughout life. Adult-born neurons and astrocytes originate from multipotent neural …
persist throughout life. Adult-born neurons and astrocytes originate from multipotent neural …