Trypanosomes as a magnifying glass for cell and molecular biology
Abstract The African trypanosome, Trypanosoma brucei, has developed into a flexible and
robust experimental model for molecular and cellular parasitology, allowing us to better …
robust experimental model for molecular and cellular parasitology, allowing us to better …
Towards solving the mystery of peroxisomal matrix protein import
ML Skowyra, P Feng, TA Rapoport - Trends in Cell Biology, 2024 - cell.com
Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …
PEX5 translocation into and out of peroxisomes drives matrix protein import
ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Protein import into peroxisomes occurs through a nuclear pore–like phase
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Peroxisome biogenesis initiated by protein phase separation
Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both
rare and prevalent diseases are caused by their dysfunction. Among disease-causing …
rare and prevalent diseases are caused by their dysfunction. Among disease-causing …
Peroxisomal cholesterol metabolism regulates yap-signaling, which maintains intestinal epithelial barrier function and is altered in Crohn's disease
Intestinal epithelial cells line the luminal surface to establish the intestinal barrier, where the
cells play essential roles in the digestion of food, absorption of nutrients and water …
cells play essential roles in the digestion of food, absorption of nutrients and water …
The essential role of fungal peroxisomes in plant infection
Several filamentous fungi are ecologically and economically important plant pathogens that
infect a broad variety of crops. They cause high annual yield losses and contaminate seeds …
infect a broad variety of crops. They cause high annual yield losses and contaminate seeds …
Insights into the structure and function of the Pex1/Pex6 AAA-ATPase in peroxisome homeostasis
RM Judy, CJ Sheedy, BM Gardner - Cells, 2022 - mdpi.com
The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …
Reconstructing the last common ancestor of all eukaryotes
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of
biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the …
biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the …
Substantial downregulation of mitochondrial and peroxisomal proteins during acute kidney injury revealed by data‐independent acquisition proteomics
JB Burton, A Silva‐Barbosa, J Bons, J Rose… - …, 2024 - Wiley Online Library
Acute kidney injury (AKI) manifests as a major health concern, particularly for the elderly.
Understanding AKI‐related proteome changes is critical for prevention and development of …
Understanding AKI‐related proteome changes is critical for prevention and development of …