Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

In contrast to the general belief, endothelial cell (EC) metabolism has recently been
identified as a driver rather than a bystander effect of angiogenesis in health and disease …

The vascular adventitia acts as a biological processing center for the retrieval, integration,
storage, and release of key regulators of vessel wall function. It is the most complex …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and
are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) …

Cells release adenosine triphosphate (ATP), which activates plasma membrane–localized
P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine …

▪ Abstract Past studies have primarily focused on how altered lung vascular growth and
development contribute to pulmonary hypertension. Recently, basic studies of vascular …