Adult neurogenesis in neurodegenerative diseases
Adult neurogenesis is limited to specific brain regions in the mammalian brain, such as the
hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in …
hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in …
α‐Synuclein oligomers and clinical implications for Parkinson disease
Protein aggregation within the central nervous system has been recognized as a defining
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients
We have previously shown that exon 1 of the huntingtin gene does not always splice to exon
2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the …
2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the …
Neurodegenerative disease and adult neurogenesis
The generation and cell death of newly generated cells have critical roles in brain
development and maintenance in the embryonic and adult brain. Alterations in these …
development and maintenance in the embryonic and adult brain. Alterations in these …
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
U Shirendeb, AP Reddy, M Manczak… - Human molecular …, 2011 - academic.oup.com
The purpose of our study was to determine the relationship between mutant huntingtin (Htt)
and mitochondrial dynamics in the progression of Huntington's disease (HD). We measured …
and mitochondrial dynamics in the progression of Huntington's disease (HD). We measured …
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
CA Elena-Real, A Sagar, A Urbanek… - Nature structural & …, 2023 - nature.com
Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …
Huntington's disease
S Finkbeiner - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Huntington's disease (HD) is the most common inherited neurodegenerative disease and is
characterized by uncontrolled excessive motor movements and cognitive and emotional …
characterized by uncontrolled excessive motor movements and cognitive and emotional …
Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease
C Landles, K Sathasivam, A Weiss, B Woodman… - Journal of Biological …, 2010 - ASBMB
Huntingtin proteolysis has been implicated in the molecular pathogenesis of Huntington
disease (HD). Despite an intense effort, the identity of the pathogenic smallest N-terminal …
disease (HD). Despite an intense effort, the identity of the pathogenic smallest N-terminal …
Soluble mutant huntingtin drives early human pathogenesis in Huntington's disease
A Miguez, C Gomis, C Vila… - Cellular and Molecular …, 2023 - Springer
Huntington's disease (HD) is an incurable inherited brain disorder characterised by massive
degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded …
degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded …
Proteins containing expanded polyglutamine tracts and neurodegenerative disease
A Adegbuyiro, F Sedighi, AW Pilkington IV… - Biochemistry, 2017 - ACS Publications
Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …