The virome in mammalian physiology and disease
HW Virgin - Cell, 2014 - cell.com
The virome contains the most abundant and fastest mutating genetic elements on Earth. The
mammalian virome is constituted of viruses that infect host cells, virus-derived elements in …
mammalian virome is constituted of viruses that infect host cells, virus-derived elements in …
Transposable elements: genome innovation, chromosome diversity, and centromere conflict
SJ Klein, RJ O'Neill - Chromosome Research, 2018 - Springer
Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jumping” from one genomic location to another, TEs are now recognized as …
discovered “jumping” from one genomic location to another, TEs are now recognized as …
Centromere repeats: hidden gems of the genome
G Hartley, RJ O'Neill - Genes, 2019 - mdpi.com
Satellite DNAs are now regarded as powerful and active contributors to genomic and
chromosomal evolution. Paired with mobile transposable elements, these repetitive …
chromosomal evolution. Paired with mobile transposable elements, these repetitive …
Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species
MV Suntsova, AA Buzdin - BMC genomics, 2020 - Springer
Chimpanzees are the closest living relatives of humans. The divergence between human
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
Unfixed endogenous retroviral insertions in the human population
E Marchi, A Kanapin, G Magiorkinis… - Journal of virology, 2014 - Am Soc Microbiol
One lineage of human endogenous retroviruses (HERVs), HERV-K (HML2), is upregulated
in many cancers, some autoimmune/inflammatory diseases, and HIV-infected cells. Despite …
in many cancers, some autoimmune/inflammatory diseases, and HIV-infected cells. Despite …
Characterizing mobile element insertions in 5675 genomes
Mobile element insertions (MEIs) are a major class of structural variants (SVs) and have
been linked to many human genetic disorders, including hemophilia, neurofibromatosis, and …
been linked to many human genetic disorders, including hemophilia, neurofibromatosis, and …
Variation in proviral content among human genomes mediated by LTR recombination
Abstract Background Human endogenous retroviruses (HERVs) occupy a substantial
fraction of the genome and impact cellular function with both beneficial and deleterious …
fraction of the genome and impact cellular function with both beneficial and deleterious …
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
S Paul, MH Kaplan, D Khanna, PM McCourt… - Nature …, 2022 - nature.com
Abstract Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite
the fact that many centromere proteins were discovered in patients with SSc. Here we report …
the fact that many centromere proteins were discovered in patients with SSc. Here we report …
Molecular functions of human endogenous retroviruses in health and disease
M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …
families and occupy~ 8% of human genome. Recent success of high-throughput …
Interplay between endogenous and exogenous human retroviruses
E Kyriakou, G Magiorkinis - Trends in Microbiology, 2023 - cell.com
In humans, retroviruses thrive more as symbionts than as parasites. Apart from the only two
modern exogenous human retroviruses (human T-cell lymphotropic and immunodeficiency …
modern exogenous human retroviruses (human T-cell lymphotropic and immunodeficiency …