T cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed on
lymphocytes that was recently propelled under the spotlight as a major emerging target in …

Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …

NKG2D ligands are widely expressed in solid and hematologic malignancies but absent or
poorly expressed on healthy tissues. We conducted a phase I dose-escalation study to …

The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …

Natural killer (NK) cells are lymphocytes of the innate immune response characterized by
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …

Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large
granular lymphocytes that belong to the innate immune system because unlike T or B …

NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of
the inhibitory receptors bind MHC class I proteins and are expressed in a variegated …

Recently, a number of clinical trials used either mesenchymal stem cells (MSCs) or natural
killer (NK) cells in an attempt to improve the effectiveness of hematopoietic stem cell …

Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …