An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are
directed against structural proteins in the skin and adjacent mucous membranes. Some …

This guideline has been initiated by the task force Autoimmune Blistering Diseases of the
European Academy of Dermatology and Venereology, including physicians from all relevant …

IL-17A has been identified as key regulatory molecule in several autoimmune and chronic
inflammatory diseases followed by the successful use of anti-IL-17 therapy, eg in ankylosing …

The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …

Laminin 332 is a heterotrimeric structural protein of the basal membrane zone (BMZ) of the
skin and adjacent mucosal tissues. The importance of laminin 332 for the structural integrity …

Background Autoimmune bullous diseases/dermatoses (AIBDs) are severe autoantibody-
mediated skin diseases. The pathogenic relevance of autoreactive CD4+ T cells for the …

Mucous membrane pemphigoid (MMP) is a mucous membrane-dominated autoimmune
subepithelial blistering disease that is caused by autoantibodies against various …

Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are
characterized by blistering of the skin and/or mucous membranes, and circulating and tissue …

Background Antilaminin 332 mucous membrane pemphigoid (MMP) is an autoimmune
subepidermal blistering disease with predominant mucosal involvement and autoantibodies …