Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …

Neural precursor cell expressed developmentally down-regulated 4 ligase (Nedd4-2) is an
E3 ubiquitin ligase that targets proteins for ubiquitination and endocytosis, thereby …

The outlined recent findings advanced our understanding of the molecular regulation of
SGK1 as well as the role of the kinase in renal physiology and the pathophysiology of renal …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …

Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating
membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion …

In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium
channels (Navs) is very important for the transmission of nociceptive information since they …

Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in
normal animal physiology and pathology. Tight regulation of these transmembrane proteins …

Compelling evidence is accumulating indicating a pathophysiological role of the serum-and-
glucocorticoid-inducible-kinase-1 (SGK1) in the development and complications of diabetes …