An up-date on Giardia and giardiasis

E Einarsson, S Ma'ayeh, SG Svärd - Current opinion in microbiology, 2016 - Elsevier
Highlights•Giardiasis is a multifactorial diarrheal disease.•Giardia infection can be protective
against other diarrheal diseases.•Giardia infection can induce IBS and chronic fatigue …

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

R Argüello-García, D Leitsch, T Skinner-Adams… - Advances in …, 2020 - Elsevier
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

Anti-Giardia Drug Discovery: Current Status and Gut Feelings

A Riches, CJS Hart, KR Trenholme… - Journal of medicinal …, 2020 - ACS Publications
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Current therapy and therapeutic targets for microsporidiosis

J Wei, Z Fei, G Pan, LM Weiss, Z Zhou - Frontiers in Microbiology, 2022 - frontiersin.org
Microsporidia are obligate intracellular, spore-forming parasitic fungi which are grouped with
the Cryptomycota. They are both opportunistic pathogens in humans and emerging …

Targeting HIF-1α function in cancer through the chaperone action of NQO1: implications of genetic diversity of NQO1

E Salido, DJ Timson, I Betancor-Fernández… - Journal of personalized …, 2022 - mdpi.com
HIF-1α is a master regulator of oxygen homeostasis involved in different stages of cancer
development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy …

Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis

B Hernández-Ochoa, V Martínez-Rosas… - Molecules, 2022 - mdpi.com
Protozoan parasites, such as Giardia lamblia and Trichomonas vaginalis, cause the most
prevalent infections in humans in developing countries and provoke significant morbidity …

Therapeutic targets for the treatment of microsporidiosis in humans

B Han, LM Weiss - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Microsporidia have been increasingly reported to infect humans. The most
common presentation of microsporidiosis is chronic diarrhea, a significant mortality risk in …

Recent advances in the development of triose phosphate isomerase inhibitors as antiprotozoal agents

LK Vázquez-Jiménez, A Moreno-Herrera… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …

Giardia lamblia G6PD::6PGL Fused Protein Inhibitors Decrease Trophozoite Viability: A New Alternative against Giardiasis

L Morales-Luna, B Hernández-Ochoa… - International Journal of …, 2022 - mdpi.com
Treatments to combat giardiasis have been reported to have several drawbacks, partly due
to the drug resistance and toxicity of current antiparasitic agents. These constraints have …

On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug

G López-Velázquez, C Fernández-Lainez… - Scientific reports, 2019 - nature.com
Research on Giardia lamblia has accumulated large information about its molecular cell
biology and infection biology. However, giardiasis is still one of the commonest parasitic …