The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner

M Hajiaghayi, F Gholizadeh, E Han, SR Little… - Frontiers in …, 2024 - frontiersin.org
Introduction Adrenergic receptors regulate metabolic, cardiovascular, and immunological
functions in response to the sympathetic nervous system. The effect of β2-adrenergic …

A Microfluidic Multiplex Sorter for Strain Development

C Leal‐Alves, S Dumont, Z Deng… - Advanced Materials …, 2024 - Wiley Online Library
Selecting strains with superior traits from strain improvement strategies is challenging, as it
involves navigating the fitness landscape by applying selective pressures that drive variants …

A Digital Microfluidic Platform for the Microscale Production of Functional Immune Cell Therapies

SR Little, N Rahbari, M Hajiaghayi, F Gholizadeh… - bioRxiv, 2024 - biorxiv.org
Genetically engineering human immune cells has been shown to be an effective approach
for developing novel cellular therapies to treat a wide range of diseases. To expand the …

Miniaturized Engineering of Human Cells using Droplet Microfluidics

S Little - 2024 - spectrum.library.concordia.ca
Inserting foreign biomolecules into human cells is at the heart of cell engineering protocols.
By taking nucleic acids or fully formed proteins and shuttling them across the cell membrane …

Highly efficient mRNA transfection with droplet cell squeezing for cellular engineering

JH Lee, A Chung - 2023 IEEE 16th International Conference on …, 2023 - ieeexplore.ieee.org
We present a novel droplet-based intracellular delivery platform for mRNA transfection. The
platform leverages the use of two immiscible fluids to encapsulate a cell and external cargos …