Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities
in immunology. While the context and classification of this group of cells has evolved …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …