Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Bestrophin-1 is an integral membrane protein, encoded by the BEST1 gene, which is
located in the basolateral membrane of the retinal pigment epithelium. The bestrophin-1 …

Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and
other monovalent anions across cellular membranes in response to intracellular calcium …

Until recently, anion (Cl−) channels have received considerably less attention than cation
channels. One reason for this may be that many Cl− channels perform functions that might …

Molecular diversity of ion channel structure and function underlies variability in electrical
signaling in nerve, muscle, and nonexcitable cells. Regulation by variable auxiliary subunits …

Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse
physiological roles, from epithelial fluid transport to sensory transduction, because their …

KCNQs are voltage-gated K+ channels that control neuronal excitability and are mutated in
epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in …

Human bestrophin-1 (hBest1) is a calcium-activated chloride channel from the retinal
pigment epithelium, where mutations are associated with vitelliform macular degeneration …

Bestrophin-1 is preferentially expressed at the basolateral membrane of the retinal
pigmented epithelium (RPE) of the retina. Mutations in the BEST1 gene cause the retinal …

Astrocytes participate in information processing by actively modulating synaptic properties
via gliotransmitter release. Various mechanisms of astrocytic release have been reported …