Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

B Damania, DP Dittmer - Journal of medical virology, 2023 - Wiley Online Library
This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that
manifests under diverse and divergent circumstances. We begin with a historical …

A prospective cohort study identifies two types of HIV+ Kaposi sarcoma lesions: proliferative and inflammatory

R Moorad, E Kasonkanji, J Gumulira… - … journal of cancer, 2023 - Wiley Online Library
Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH) in many
countries where KS‐associated herpesvirus is endemic. Treatment has changed little in 20 …

Adaptive immune responses to Kaposi's sarcoma-associated herpesvirus

A Nalwoga, D Whitby - Current opinion in immunology, 2022 - Elsevier
Highlights•T cell responses to KSHV are diverse and weak compared to other
herpesviruses.•CD8+ T cells in KS tumours are localised to regions that are KSHV LANA …

[HTML][HTML] Macrophages drive KSHV B cell latency

A Szymula, G Samayoa-Reyes, S Ogolla, B Liu, S Li… - Cell reports, 2023 - cell.com
Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong infection and persists in latently
infected B cells. Paradoxically, in vitro B cell infection is inefficient, and cells rapidly die …

[HTML][HTML] Pediatric HIV+ Kaposi sarcoma exhibits clinical, virological, and molecular features different from the adult disease

C Caro-Vegas, A Peng, A Juarez, A Silverstein… - JCI insight, 2023 - ncbi.nlm.nih.gov
BACKGROUND Kaposi sarcoma (KS) is among the most common childhood cancers in
Eastern and Central Africa. Pediatric KS has a distinctive clinical presentation compared …

Whole-genome sequencing of Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) reveals evidence for two African Lineages

R Moorad, A Juarez, JT Landis, LJ Pluta, M Perkins… - Virology, 2022 - Elsevier
Kaposi sarcoma (KS)-associated herpesvirus (KSHV/HHV-8) was first sequenced from the
body cavity (BC) lymphoma cell line, BC-1, in 1996. Few other KSHV genomes have been …

Immunization of mice with virus-like vesicles of Kaposi Sarcoma-associated herpesvirus reveals a role for antibodies targeting ORF4 in activating complement …

AK Lam, R Roshan, W Miley, N Labo, J Zhen… - Journal of …, 2023 - Am Soc Microbiol
Infection by Kaposi sarcoma-associated herpesvirus (KSHV) can cause severe
consequences, such as cancers and lymphoproliferative diseases. Whole inactivated …

Viral Load Measurements for Kaposi Sarcoma Herpesvirus (KSHV/HHV8): Review and an Updated Assay

P Cano, T Seltzer, J Seltzer, A Peng… - Journal of Medical …, 2024 - Wiley Online Library
ABSTRACT “When you can measure what you are speaking about, and express it in
numbers, you know something about it.” is a famous quote attributed to Lord Kelvin. This …

Immune cell phenotype and function patterns across the life course in individuals from rural Uganda

A Nalwoga, M Nakibuule, R Roshan… - Frontiers in …, 2024 - frontiersin.org
Background To determine the pattern of immune cell subsets across the life span in rural
sub-Saharan Africa (SSA), and to set a reference standard for cell subsets amongst Africans …

Effects of Maternal HIV Infection on Early Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Kenyan Mother-Infant Cohort

KR Sabourin, S Ogolla, GS Reyes… - The Journal of …, 2023 - academic.oup.com
Background We identified whether maternal human immunodeficiency virus (HIV) infection
during pregnancy affects transplacental transfer of Kaposi sarcoma-associated herpesvirus …