The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

The proteasome is the central component of the main cellular protein degradation pathway.
During the past four decades, the critical function of the proteasome in numerous …

Increasing evidence reveals a close relationship between deubiquitinating enzymes (DUBs)
and cancer progression. In this study, we attempted to identify the roles and mechanisms of …

The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …

Metastasis and chemoresistance are major causes of poor prognosis in patients with
esophageal squamous cell carcinoma (ESCC), manipulated by multiple factors including …

Virtual screening is receiving renewed attention in drug discovery, but progress is hampered
by challenges on two fronts: handling the ever-increasing sizes of libraries of drug-like …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

PSMD14 is a 19S-proteasome-associated deubiquitinating enzyme that facilitates protein
degradation by the 20S proteasome core particle. Although accumulating evidence …