Epigenetic dysregulations in merkel cell polyomavirus-driven merkel cell carcinoma

JC Rotondo, C Mazziotta, C Lanzillotti… - International Journal of …, 2021 - mdpi.com
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is
the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the …

Role of virus-induced host cell epigenetic changes in cancer

V Pietropaolo, C Prezioso, U Moens - International Journal of Molecular …, 2021 - mdpi.com
The tumor viruses human T-lymphotropic virus 1 (HTLV-1), hepatitis C virus (HCV), Merkel
cell polyomavirus (MCPyV), high-risk human papillomaviruses (HR-HPVs), Epstein-Barr …

Expression of mismatch repair proteins in Merkel cell carcinoma

T Gambichler, N Abu Rached, A Tannapfel, JC Becker… - Cancers, 2021 - mdpi.com
Simple Summary Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer
with neuroendocrine differentiation. About 80% are Merkel cell polyomavirus (MCPyV) …

PTCH1 Gene Variants, mRNA Expression, and Bioinformatics Insights in Mexican Cutaneous Squamous Cell Carcinoma Patients

M Zambrano-Román, JR Padilla-Gutiérrez, Y Valle… - Biology, 2024 - mdpi.com
Simple Summary Skin cancer represents a prevalent and significant global health concern.
Our study focused on comprehending cutaneous squamous cell carcinoma in the Mexican …

The Antineoplastic Effect of Dimethyl Fumarate on Virus-Negative Merkel Cell Carcinoma Cell Lines: Preliminary Results

T Gambichler, LG Brüggestrat, M Skrygan, CH Scheel… - Cancers, 2023 - mdpi.com
Simple Summary Merkel cell carcinoma (MCC) is an aggressive skin cancer with limited
treatment options for the advanced disease once immunotherapy has failed. MCC …

The emerging role of hedgehog signaling in viral infections

Y Zhou, J Huang, B Jin, S He, Y Dang, T Zhao… - Frontiers in …, 2022 - frontiersin.org
The hedgehog (HH) signaling pathway is one of the key pathways that is indispensable for
many developmental processes and postnatal tissue homeostasis. Dysregulated HH …

PTCH1 gene variants rs357564, rs2236405, rs2297086 and rs41313327, mRNA and tissue expression in basal cell carcinoma patients from Western Mexico

M Zambrano‐Román… - Journal of Clinical …, 2024 - Wiley Online Library
Background Basal cell carcinoma (BCC) represents about 80% of all cases of skin cancer.
The PTCH1 is a transmembrane protein of the Sonic Hedgehog signaling pathway that …

Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models

EA Pedersen, ME Verhaegen, MK Joseph… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma
thought to arise via either viral (Merkel cell polyomavirus) or ultraviolet-associated pathways …

Inhibition of the drug efflux activity of Ptch1 as a promising strategy to overcome chemotherapy resistance in cancer cells

S Kovachka, G Malloci, M Simsir, P Ruggerone… - European Journal of …, 2022 - Elsevier
The development of inhibitors of key biological mechanisms involved in multidrug resistance
(MDR) burden meets an important medical need but still represents a challenging task …

Expression der Moleküle des Hedgehog-Signaltransduktionsweges im mikrozystischen Adnexkarzinom im Vergleich zum Syringom, Trichoepitheliom und …

I Hartenstein - 2022 - hss-opus.ub.ruhr-unibochum.de
Wir untersuchten die Expression der Moleküle des Hedgehog-Signaltransduktionsweges im
mikrozystischen Adnexkarzinom im Vergleich zum Syringom, Trichoepitheliom und …