Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation

R Pan, L Wang, X Xu, Y Chen, H Wang, G Wang… - Nutrients, 2022 - mdpi.com
Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder.
Accumulating evidence highlights the link between imbalances in the gut microbiome and …

Action mode of gut motility, fluid and electrolyte transport in chronic constipation

Q Zhao, YY Chen, DQ Xu, SJ Yue, RJ Fu… - Frontiers in …, 2021 - frontiersin.org
Chronic constipation is a common gastrointestinal disorder, with a worldwide incidence of
14–30%. It negatively affects quality of life and is associated with a considerable economic …

Houpo paiqi mixture promotes intestinal motility in constipated rats by modulating gut microbiota and activating 5-HT-cAMP-PKA signal pathway

R Wang, X Lu, L Zhao, W Zhang… - Journal of applied …, 2023 - academic.oup.com
Aims Constipation is a common functional gastrointestinal disorder, which needs more
effective treatment approaches. Houpo Paiqi Mixture (HPPQM) is a type of Chinese patent …

Current overview on clinical management of chronic constipation

J Włodarczyk, A Waśniewska, J Fichna, A Dziki… - Journal of Clinical …, 2021 - mdpi.com
Constipation is one of the major gastrointestinal disorders diagnosed in clinical practice in
Western countries. Almost 20% of population suffer from this disorder, which means …

Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome

IF Shaidullov, DM Sorokina, FG Sitdikov… - BMC …, 2021 - Springer
Background Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated
with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut …

[HTML][HTML] Effect of the probiotic strain, Lactiplantibacillus plantarum P9, on chronic constipation: A randomized, double-blind, placebo-controlled study

T Ma, N Yang, Y Xie, Y Li, Q Xiao, Q Li, H Jin… - Pharmacological …, 2023 - Elsevier
Chronic constipation (CC) is a common gastrointestinal condition associated with intestinal
inflammation, and the condition considerably impairs patients' quality of life. We conducted a …

Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation

H Kim, EJ Jeong, C Park, J Lee, WJ Kim, KW Yu… - International Journal of …, 2023 - Elsevier
The present study aimed to investigate the effect of oral administration of snail-derived
mucin extract (SM) on ameliorating constipation symptoms of loperamide-induced …

[HTML][HTML] Mendelian-randomization study reveals causal relationships between nitrogen dioxide and gut microbiota

H Yang, P Shi, M Li, L Kong, S Liu, L Jiang… - Ecotoxicology and …, 2023 - Elsevier
Exposure to nitrogen dioxide might potentially change the makeup and operation of gut
microbes. Nitrogen dioxide data was procured from the IEU Open GWAS (N= 456 380) …

Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and …

Y Makizaki, T Uemoto, H Yokota, M Yamamoto… - PLoS …, 2021 - journals.plos.org
A treatment option for constipation that improves the quality of life is needed since available
laxatives do not effectively improve the quality of life in patients with constipation. A …

The interplay between nutrition, innate immunity, and the commensal microbiota in adaptive intestinal morphogenesis

F Bayer, O Dremova, MP Khuu, K Mammadova… - Nutrients, 2021 - mdpi.com
The gastrointestinal tract is a functionally and anatomically segmented organ that is
colonized by microbial communities from birth. While the genetics of mouse gut …