Challenging the ischemic core concept in acute ischemic stroke imaging

M Goyal, JM Ospel, B Menon, M Almekhlafi… - Stroke, 2020 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion and has recently revolutionized stroke care. Oftentimes, ischemic core …

Multiphase adjuvant neuroprotection: a novel paradigm for improving acute ischemic stroke outcomes

W Zhao, C Wu, D Dornbos III, S Li, H Song… - Brain …, 2020 - journals.lww.com
While several large pivotal clinical trials recently revealed a substantial benefit of
endovascular thrombectomy for acute ischemic stroke (AIS) caused by large-vessel …

Mediation of the relationship between endovascular therapy and functional outcome by follow-up infarct volume in patients with acute ischemic stroke

AMM Boers, IGH Jansen, S Brown, HF Lingsma… - JAMA …, 2019 - jamanetwork.com
Importance The positive treatment effect of endovascular therapy (EVT) is assumed to be
caused by the preservation of brain tissue. It remains unclear to what extent the treatment …

A detailed analysis of infarct patterns and volumes at 24-hour noncontrast CT and diffusion-weighted MRI in acute ischemic stroke due to large vessel occlusion …

JM Ospel, BK Menon, W Qiu, N Kashani, A Mayank… - Radiology, 2021 - pubs.rsna.org
Background The effect of infarct pattern on functional outcome in acute ischemic stroke is
incompletely understood. Purpose To investigate the association of qualitative and …

In-Silico Trials for Treatment of Acute Ischemic Stroke

PR Konduri, HA Marquering, EE Van Bavel… - Frontiers in …, 2020 - frontiersin.org
Despite improved treatment, a large portion of patients with acute ischemic stroke due to a
large vessel occlusion have poor functional outcome. Further research exploring novel …

Predictors of futile recanalization in patients undergoing endovascular treatment in the DIRECT-MT trial

T Zhou, T Yi, T Li, L Zhu, Y Li, Z Li, M Wang… - Journal of …, 2022 - jnis.bmj.com
Background Futile recanalization—when patients have a successful recanalization but fail to
achieve a satisfactory functional outcome—is a common phenomenon of endovascular …

Assessment of discrepancies between follow-up infarct volume and 90-day outcomes among patients with ischemic stroke who received endovascular therapy

A Ganesh, JM Ospel, BK Menon… - JAMA network …, 2021 - jamanetwork.com
Importance Some patients have poor outcomes despite small infarcts after endovascular
therapy (EVT), while others with large infarcts do well. Understanding why these …

Surface electroencephalography (EEG) during the acute phase of stroke to assist with diagnosis and prediction of prognosis: a scoping review

L Sutcliffe, H Lumley, L Shaw, R Francis… - BMC emergency …, 2022 - Springer
Background Stroke is a common medical emergency responsible for significant mortality
and disability. Early identification improves outcomes by promoting access to time-critical …

Identifying large ischemic core volume ranges in acute stroke that can benefit from mechanical thrombectomy

T Yoshimoto, M Inoue, K Tanaka… - Journal of …, 2021 - jnis.bmj.com
Background We aimed to identify the large ischemic core (LIC) volume ranges in acute
ischemic stroke patients that can benefit from mechanical thrombectomy (MT). Methods …

Predictors of poor outcome despite successful endovascular treatment for ischemic stroke: results from the MR CLEAN Registry

RA van de Graaf, N Samuels, V Chalos… - Journal of …, 2022 - jnis.bmj.com
Background Approximately one-third of patients with ischemic stroke treated with
endovascular treatment do not recover to functional independence despite rapid and …