The roles of optogenetics and technology in neurobiology: a review
Optogenetic is a technique that combines optics and genetics to control specific neurons.
This technique usually uses adenoviruses that encode photosensitive protein. The …
This technique usually uses adenoviruses that encode photosensitive protein. The …
Basal forebrain projections to the lateral habenula modulate aggression reward
Maladaptive aggressive behaviour is associated with a number of neuropsychiatric
disorders and is thought to result partly from the inappropriate activation of brain reward …
disorders and is thought to result partly from the inappropriate activation of brain reward …
Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology
RJ Sizemore, S Seeger-Armbruster… - Journal of …, 2016 - journals.physiology.org
Viral vectors were originally developed to deliver genes into host cells for therapeutic
potential. However, viral vector use in neuroscience research has increased because they …
potential. However, viral vector use in neuroscience research has increased because they …
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning
J Sala-Bayo, L Fiddian, SRO Nilsson… - …, 2020 - nature.com
Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide
range of neurological and neuropsychiatric disorders. Although both human and animal …
range of neurological and neuropsychiatric disorders. Although both human and animal …
Optogenetic activation of adenosine A2A receptor signaling in the dorsomedial striatopallidal neurons suppresses goal-directed behavior
Y Li, Y He, M Chen, Z Pu, L Chen, P Li, B Li… - …, 2016 - nature.com
The striatum has an essential role in neural control of instrumental behaviors by
reinforcement learning. Adenosine A 2A receptors (A 2A Rs) are highly enriched in the …
reinforcement learning. Adenosine A 2A receptors (A 2A Rs) are highly enriched in the …
Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms
H Shang, P Li, X Lin, Q Cai, Z Li, L Deng… - …, 2023 - nature.com
Several cognitive processes, including instrumental behavior and working memory, are
controlled by endocannabinoids acting on cannabinoid receptor 1 (CB1R) in the brain …
controlled by endocannabinoids acting on cannabinoid receptor 1 (CB1R) in the brain …
An approach to monitoring home-cage behavior in mice that facilitates data sharing
Genetically modified mice are used as models for a variety of human behavioral conditions.
However, behavioral phenotyping can be a major bottleneck in mouse genetics because …
However, behavioral phenotyping can be a major bottleneck in mouse genetics because …
WONOEP APPRAISAL: the many facets of epilepsy networks
RC Scott, L Menendez de la Prida, JM Mahoney… - …, 2018 - Wiley Online Library
The brain is a complex system composed of networks of interacting elements, from genes to
circuits, whose function (and dysfunction) is not derivable from the superposition of …
circuits, whose function (and dysfunction) is not derivable from the superposition of …
Catecholaminergic modulation of indices of cognitive flexibility: a pharmaco-tDCS study
Background Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been
implicated in the control of cognitive flexibility. Much of the evidence for a causative …
implicated in the control of cognitive flexibility. Much of the evidence for a causative …
Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies
Neurodevelopmental proteasomopathies represent a distinctive category of
neurodevelopmental disorders (NDD) characterized by genetic variations within the 26S …
neurodevelopmental disorders (NDD) characterized by genetic variations within the 26S …