The origin, evolution and structure of the protein world
G Caetano-Anollés, M Wang… - Biochemical …, 2009 - portlandpress.com
Contemporary protein architectures can be regarded as molecular fossils, historical imprints
that mark important milestones in the history of life. Whereas sequences change at a …
that mark important milestones in the history of life. Whereas sequences change at a …
When less is more: sketching with minimizers in genomics
The exponential increase in sequencing data calls for conceptual and computational
advances to extract useful biological insights. One such advance, minimizers, allows for …
advances to extract useful biological insights. One such advance, minimizers, allows for …
[图书][B] Introduction to proteins: structure, function, and motion
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments
Here, a scalable, accurate, reliable, and robust protein functional site comparison algorithm
is presented. The key components of the algorithm consist of a reduced representation of the …
is presented. The key components of the algorithm consist of a reduced representation of the …
Bridging themes: short protein segments found in different architectures
The vast majority of theoretically possible polypeptide chains do not fold, let alone confer
function. Hence, protein evolution from preexisting building blocks has clear potential …
function. Hence, protein evolution from preexisting building blocks has clear potential …
Mathematical modeling and comparison of protein size distribution in different plant, animal, fungal and microbial species reveals a negative correlation between …
A Tiessen, P Pérez-Rodríguez… - BMC research …, 2012 - Springer
Background The sizes of proteins are relevant to their biochemical structure and for their
biological function. The statistical distribution of protein lengths across a diverse set of taxa …
biological function. The statistical distribution of protein lengths across a diverse set of taxa …
The CATH classification revisited—architectures reviewed and new ways to characterize structural divergence in superfamilies
AL Cuff, I Sillitoe, T Lewis, OC Redfern… - Nucleic acids …, 2009 - academic.oup.com
The latest version of CATH (class, architecture, topology, homology)(version 3.2), released
in July 2008 (http://www. cathdb. info), contains 1 14 215 domains, 2178 Homologous …
in July 2008 (http://www. cathdb. info), contains 1 14 215 domains, 2178 Homologous …
GTalign: spatial index-driven protein structure alignment, superposition, and search
M Margelevičius - Nature Communications, 2024 - nature.com
With protein databases growing rapidly due to advances in structural and computational
biology, the ability to accurately align and rapidly search protein structures has become …
biology, the ability to accurately align and rapidly search protein structures has become …
Exploration of uncharted regions of the protein universe
L Jaroszewski, Z Li, SS Krishna, C Bakolitsa… - PLoS …, 2009 - journals.plos.org
The genome projects have unearthed an enormous diversity of genes of unknown function
that are still awaiting biological and biochemical characterization. These genes, as most …
that are still awaiting biological and biochemical characterization. These genes, as most …
Exploring the structure and function paradigm
Advances in protein structure determination, led by the structural genomics initiatives have
increased the proportion of novel folds deposited in the Protein Data Bank. However, these …
increased the proportion of novel folds deposited in the Protein Data Bank. However, these …