[HTML][HTML] Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans
Saccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein
formulations. The current work reviewed the stabilization mechanisms of three groups of …
formulations. The current work reviewed the stabilization mechanisms of three groups of …
Enabling efficient design of biological formulations through advanced characterization
The present review summarizes the use of differential scanning calorimetry (DSC) and
scattering techniques in the context of protein formulation design and characterization. The …
scattering techniques in the context of protein formulation design and characterization. The …
Pulmonary drug delivery technology enables anakinra repurposing in cystic fibrosis
M Puccetti, M Pariano, C Stincardini, P Wojtylo… - Journal of Controlled …, 2023 - Elsevier
Inflammation is a key pathological driver in cystic fibrosis (CF). Current therapies are
ineffective in treating and preventing the escalation of inflammatory events often …
ineffective in treating and preventing the escalation of inflammatory events often …
Dual Functionality of Poloxamer 188 in Freeze-Dried Protein Formulations: A Stabilizer in Frozen Solutions and a Bulking Agent in Lyophiles
J Li, B Munjal, C Zeng… - Molecular …, 2024 - ACS Publications
Poloxamer 188 (P188) was hypothesized to be a dual functional excipient,(i) a stabilizer in
frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent …
frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent …
Specific surface area of mannitol rather than particle size dominant the dissolution rate of poorly water-soluble drug tablets: A study of binary mixture
K Zhang, S Qian, Z Liu, H Liu, Z Lin, W Heng… - International Journal of …, 2024 - Elsevier
The dissolution behavior of tablets, particularly those containing poorly water-soluble drugs,
is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the …
is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the …