The search for innovative anti-cancer drugs remains a challenge. Over the past three
decades, antibodies have emerged as an essential asset in successful cancer therapy. The …

Cancer poses a significant health challenge, with traditional treatments like surgery,
radiotherapy, and chemotherapy often lacking in cell specificity and long‐term curative …

T cell-based adoptive cell therapy (ACT) has emerged as a promising treatment for various
diseases, particularly cancers. Unlike other immunotherapy modalities, ACT involves directly …

Cancer is among the leading causes of death worldwide. Therefore, improving cancer
therapeutic strategies using novel alternatives is a top priority on the contemporary scientific …

Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell
fratricide and require additional engineering to mitigate self-damage. We demonstrate that …

Engineered T cell therapies such as CAR-T cells and TCR-T cells have generated
impressive patient responses in previously incurable diseases. In the past few years there …

Cell therapies based on T cell have gathered interest over the last decades for treatment of
cancers, becoming recently the most investigated lineage for clinical trials. Although results …

Messenger RNA (mRNA) has emerged as an innovative therapeutic modality, offering
promising avenues for the prevention and treatment of a variety of diseases. The …

Suspension cell culture and rigid commercial substrates are the most common methods to
clinically manufacture therapeutic CAR-T cells ex vivo. However, suspension culture and …

Highlights•High costs and regulatory hurdles associated with viral vectors for CAR T
therapies.•Non-viral gene delivery may overcome limitations of viral vector gene …