Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders

B Polis, AO Samson - Neural regeneration research, 2020 - journals.lww.com
Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …

[HTML][HTML] Alzheimer's disease as a chronic maladaptive polyamine stress response

B Polis, D Karasik, AO Samson - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Alzheimer’s disease as a chronic maladaptive polyamine stress response - PMC Back to Top
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …

[HTML][HTML] A new perspective on Alzheimer's disease as a brain expression of a complex metabolic disorder

B Polis, AO Samson - Alzheimer's Disease [Internet], 2019 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an irredeemable chronic neurodegenerative disorder and the
predominant cause of dementia. The disease progression is associated with the deposition …

Pectin with various degrees of esterification differentially alters gut microbiota and metabolome of healthy adults

W Huang, Q Fang, L Fan, T Hong, H Tan, S Nie - Efood, 2022 - Wiley Online Library
Pectin with various degrees of esterification (DE) leads to different food processing
directions and has the distinct potential for modulating human health. Investigations of pectin …

Mitochondrial metabolism: A common link between neuroinflammation and neurodegeneration

D Garabadu, N Agrawal, A Sharma… - Behavioural …, 2019 - journals.lww.com
Neurodegenerative disorders have been considered as a growing health concern for
decades. Increasing risk of neurodegenerative disorders creates a socioeconomic burden to …

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

JR Sullivan, A Lupien, E Kalthoff, C Hamela… - PLoS …, 2021 - journals.plos.org
Mycobacterium abscessus is the most common rapidly growing non-tuberculous
mycobacteria to cause pulmonary disease in patients with impaired lung function such as …

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment

X Zheng, S Mansouri, A Krager… - European …, 2020 - Eur Respiratory Soc
Lung cancer is the leading cause of death from cancer worldwide. Recent studies
demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression …

Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats

H Javrushyan, E Nadiryan, A Grigoryan… - … and molecular pathology, 2022 - Elsevier
Background A decrease in nitric oxide (NO) bioavailability has been shown to cause
hyperglycemia, type II diabetes mellitus (DM), and chronic cardio-metabolic complications …

Non-targeted metabolomics study for discovery of hepatocellular carcinoma serum diagnostic biomarker

S Wang, T He, H Wang - Journal of Pharmaceutical and Biomedical …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant cancers worldwide.
Due to the asymptomatic features of HCC at early stages, patients are often diagnosed at …

Effects of chronic arginase inhibition with Norvaline on tau pathology and brain glucose metabolism in Alzheimer's disease mice

B Polis, M Squillario, V Gurevich, KD Srikanth… - Neurochemical …, 2022 - Springer
Alzheimer's disease (AD) is an insidious neurodegenerative disorder representing a serious
continuously escalating medico-social problem. The AD-associated progressive dementia is …