The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
Microbiota from young mice counteracts selective age-associated behavioral deficits
The gut microbiota is increasingly recognized as an important regulator of host immunity and
brain health. The aging process yields dramatic alterations in the microbiota, which is linked …
brain health. The aging process yields dramatic alterations in the microbiota, which is linked …
Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis
S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …
cognitive function and mental health. Recent research has positioned the gut microbiota as …
The potential role of inflammation in modulating endogenous hippocampal neurogenesis after spinal cord injury
A Sefiani, CG Geoffroy - Frontiers in Neuroscience, 2021 - frontiersin.org
Currently there are approximately 291,000 people suffering from a spinal cord injury (SCI) in
the United States. SCI is associated with traumatic changes in mobility and neuralgia, as …
the United States. SCI is associated with traumatic changes in mobility and neuralgia, as …
Enriched environment attenuates enhanced trait anxiety in association with normalization of aberrant neuro-inflammatory events
A Sah, S Rooney, M Kharitonova, SB Sartori… - International Journal of …, 2022 - mdpi.com
Neuroinflammation is discussed to play a role in specific subgroups of different psychiatric
disorders, including anxiety disorders. We have previously shown that a mouse model of …
disorders, including anxiety disorders. We have previously shown that a mouse model of …
Targeting hippocampal neurogenesis to protect astronauts' cognition and mood from decline due to space radiation effects
Neurogenesis is an essential, lifelong process during which neural stem cells generate new
neurons within the hippocampus, a center for learning, memory, and mood control. Neural …
neurons within the hippocampus, a center for learning, memory, and mood control. Neural …
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
TLX, an orphan nuclear receptor with emerging roles in physiology and disease
Abstract TLX (NR2E1), an orphan member of the nuclear receptor superfamily, is a
transcription factor that has been described to be generally repressive in nature. It has been …
transcription factor that has been described to be generally repressive in nature. It has been …
Developmental IL-6 exposure favors production of PDGF-responsive multipotential progenitors at the expense of neural stem cells and other progenitors
E Kumari, FJ Velloso, A Nasuhidehnavi… - Stem cell reports, 2020 - cell.com
Summary Interleukin-6 (IL-6) is increased in maternal serum and amniotic fluid of children
subsequently diagnosed with autism spectrum disorders. However, it is not clear how …
subsequently diagnosed with autism spectrum disorders. However, it is not clear how …
Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus
N Li, L Cui, G Song, L Guo, H Gu, H Cao… - Frontiers in Cellular …, 2018 - frontiersin.org
Disrupted-in-schizophrenia 1 (DISC1) is a strong candidate susceptibility gene for a
spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major …
spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major …