A molecular biology–based taxonomy has been proposed for pheochromocytoma and
paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant …

The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate
dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two …

Objective: The aim was to formulate clinical practice guidelines for pheochromocytoma and
paraganglioma (PPGL). Participants: The Task Force included a chair selected by the …

Hereditary pheochromocytoma (PCC) is often caused by germline mutations in one of nine
susceptibility genes described to date,,,, but there are familial cases without mutations in …

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors
of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can …

Purpose: Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically
heterogeneous neural crest–derived neoplasms. Recently we identified germline mutations …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are catecholamine-secreting
tumors of neural crest origin. Once collectively known as the '10% tumor', based on the …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

BACKGROUND Pheochromocytomas are rare catecholamine-producing tumors derived in
more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date …