The vascular endothelium in chronic kidney disease: a novel target for aerobic exercise

CR Martens, DL Kirkman… - Exercise and sport …, 2016 - journals.lww.com
MARTENS, CR, DL KIRKMAN, and DG EDWARDS. The vascular endothelium in chronic
kidney disease: a novel target for aerobic exercise. Exerc. Sport Sci. Rev., Vol. 44, No. 1, pp …

Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats

IF Schwartz, A Grupper, T Chernichovski… - Journal of vascular …, 2011 - karger.com
Objectives: Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial
nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid …

Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease

CR Martens, JM Kuczmarski… - Journal of …, 2014 - journals.lww.com
Reduced nitric oxide bioavailability contributes to increased cardiovascular disease risk in
patients with chronic kidney disease (CKD). Arginase has been implicated as a potential …

Matrine attenuates high‐fat diet‐induced in vivo and ox‐LDL‐induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways

S Zhang, S Guo, X Gao, A Liu, W Jiang… - Journal of Cellular …, 2019 - Wiley Online Library
Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that
has been used to improve obesity and diabetes and for the treatment of hepatitis B …

Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1

OS Bentur, D Schwartz… - American Journal …, 2015 - journals.physiology.org
Decreased generation of nitric oxide (NO) by endothelial NO synthase (eNOS) characterizes
endothelial dysfunction (ECD). Delivery of arginine to eNOS by cationic amino acid …

[HTML][HTML] Streptozotocin-induced vascular and biochemical changes in rats: Effects of rosiglitazone vs. metformin

DO Saleh, AR Bayoumi, WI El-Eraky… - Bulletin of faculty of …, 2013 - Elsevier
The aim was to investigate rosiglitazone and metformin effects on some vascular and
biochemical changes associated with streptozotocin (55 mg/kg; ip)-induced hyperglycaemia …

Vascular endothelial growth factor augments arginine transport and nitric oxide generation via a KDR receptor signaling pathway

M Shashar, T Chernichovski, O Pasvolsky… - Kidney and Blood …, 2017 - karger.com
Abstract Background/Aims: Vascular endothelial growth factor (VEGF) is an endothelium-
specific peptide that stimulates angiogenesis via two receptor tyrosine kinases, Flt-1 and …

Voluntary wheel running augments aortic l-arginine transport and endothelial function in rats with chronic kidney disease

CR Martens, JM Kuczmarski, J Kim… - American Journal …, 2014 - journals.physiology.org
Reduced nitric oxide (NO) synthesis contributes to risk for cardiovascular disease in chronic
kidney disease (CKD). Vascular uptake of the NO precursor l-arginine (ARG) is attenuated in …

Cyclosporine attenuates arginine transport, in human endothelial cells, through modulation of cationic amino acid transporter-1

A Grupper, M Shashar, D Bahry, Y Pri-Paz… - American journal of …, 2013 - karger.com
Background: The spectrum of cardiovascular toxicity by cyclosporine (CsA) includes
hypertension, accelerated atherosclerosis, and thrombotic microangiopathy, all of which are …

Profound decrease in glomerular arginine transport by CAT (cationic amino acid transporter)-1 contributes to the FLT-1 (FMS-like tyrosine kinase 1) induced …

M Shashar, A Zubkov, T Chernichovski… - …, 2019 - Am Heart Assoc
Endothelial dysfunction because of nitric oxide inactivation has been suggested to play a
role in the pathogenesis of preeclampsia. During pregnancy, L-arginine transport by CAT-1 …