Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
[HTML][HTML] Amyloid-β and tau complexity—towards improved biomarkers and targeted therapies
JC Polanco, C Li, LG Bodea… - Nature Reviews …, 2018 - nature.com
Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
The preclinical phase of the pathological process underlying sporadic Alzheimer's disease
H Braak, K Del Tredici - Brain, 2015 - academic.oup.com
Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years
H Braak, DR Thal, E Ghebremedhin… - … of Neuropathology & …, 2011 - academic.oup.com
Two thousand three hundred and thirty two nonselected brains from 1-to 100-year-old
individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for …
individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for …
Tau in Alzheimer disease and related tauopathies
Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …
Structure and pathology of tau protein in Alzheimer disease
M Kolarova, F García-Sierra, A Bartos… - International journal …, 2012 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …
global trend of prolonging human life and the increasing number of elderly in the population …
The pathological process underlying Alzheimer's disease in individuals under thirty
H Braak, K Del Tredici - Acta neuropathologica, 2011 - Springer
Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8,
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …
Mechanisms of tau-induced neurodegeneration
Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a
specific type of slow and progressive neurodegeneration, which involves the abnormal …
specific type of slow and progressive neurodegeneration, which involves the abnormal …
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or …
Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies
including Alzheimer's disease (AD) and corticobasal degeneration (CBD) which show cell …
including Alzheimer's disease (AD) and corticobasal degeneration (CBD) which show cell …