Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures
SB Plaisier, R Taschereau, JA Wong… - Nucleic acids …, 2010 - academic.oup.com
Comparing independent high-throughput gene-expression experiments can generate
hypotheses about which gene-expression programs are shared between particular …
hypotheses about which gene-expression programs are shared between particular …
Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites
Background Psoriasis is a cytokine-mediated skin disease that can be treated effectively
with immunosuppressive biologic agents. These medications, however, are not equally …
with immunosuppressive biologic agents. These medications, however, are not equally …
Isosorbide fatty acid diesters have synergistic anti-inflammatory effects in cytokine-induced tissue culture models of atopic dermatitis
WR Swindell, K Bojanowski, RK Chaudhuri - International journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a chronic disease in which epidermal barrier disruption triggers Th2-
mediated eruption of eczematous lesions. Topical emollients are a cornerstone of chronic …
mediated eruption of eczematous lesions. Topical emollients are a cornerstone of chronic …
Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords
WR Swindell - Frontiers in Genetics, 2024 - frontiersin.org
Introduction ALS is a fatal neurodegenerative disease for which underlying mechanisms are
incompletely understood. The motor neuron is a central player in ALS pathogenesis but …
incompletely understood. The motor neuron is a central player in ALS pathogenesis but …
[HTML][HTML] Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue
Caloric restriction (CR) has been extensively studied in rodents as an intervention to
improve lifespan and healthspan. However, effects of CR can be strain-and species-specific …
improve lifespan and healthspan. However, effects of CR can be strain-and species-specific …
Farm Household Vulnerability Due to Land and Forest Fire in Peatland Areas in South Sumatra
Land and forest fires in peatland areas in Indonesia have a widespread negative impact on
surrounding communities. Possible vulnerabilities relate to economic, social, ecological …
surrounding communities. Possible vulnerabilities relate to economic, social, ecological …
A generalized dSpliceType framework to detect differential splicing and differential expression events using RNA-Seq
Transcriptomes are routinely compared in term of a list of differentially expressed genes
followed by functional enrichment analysis. Due to the technology limitations of microarray …
followed by functional enrichment analysis. Due to the technology limitations of microarray …
Consistency analysis of redundant probe sets on affymetrix three-prime expression arrays and applications to differential mRNA processing
X Cui, AE Loraine - PLoS One, 2009 - journals.plos.org
Affymetrix three-prime expression microarrays contain thousands of redundant probe sets
that interrogate different regions of the same gene. Differential expression analysis methods …
that interrogate different regions of the same gene. Differential expression analysis methods …
Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data
Abstract Background The Affymetrix GeneChip is a widely used gene expression profiling
platform. Since the chips were originally designed, the genome databases and gene …
platform. Since the chips were originally designed, the genome databases and gene …
Genetic profiling of young and aged endothelial progenitor cells in hypoxia
TW Wu, CC Liu, CL Hung, CH Yen, YJ Wu, LY Wang… - PLoS …, 2018 - journals.plos.org
Age is a major risk factor for diseases caused by ischemic hypoxia, such as stroke and
coronary artery disease. Endothelial progenitor cells (EPCs) are the major cells respond to …
coronary artery disease. Endothelial progenitor cells (EPCs) are the major cells respond to …