Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of
biological properties and functions especially in immune responses. In addition, increasing …

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC).
Here, we investigated the effect of perineural invasion on the microenvironment and how …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The
risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors …

Many advanced cancers are characterized by metabolic disorders. A dietary therapeutic
strategy was proposed to inhibit tumor growth through administration of low-carbohydrate …

Background & Aims Cigarette smoke has been identified as an independent risk factor for
chronic pancreatitis (CP). Little is known about the mechanisms by which smoking promotes …

The progression of cancer is a result of not only the growth of the malignant cells but also the
behavior of other components of the tumor microenvironment (TME). Tumor-associated …

Background & Aims Growth, progression, and drug resistance of pancreatic ductal
adenocarcinomas (PDACs) have been associated with increased levels and activity of …

Some diets, such as high lipid and high glucose diets, are known to increase the risk of
colorectal cancer. On the other hand, little is known about diets that prevent colonic …