Podoplanin in inflammation and cancer

M Quintanilla, L Montero-Montero, J Renart… - International journal of …, 2019 - mdpi.com
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Fibroblast-like synoviocytes in rheumatoid arthritis: surface markers and phenotypes

Z Wu, D Ma, H Yang, J Gao, G Zhang, K Xu… - International …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects
synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive …

Roles of podoplanin in malignant progression of tumor

H Suzuki, MK Kaneko, Y Kato - Cells, 2022 - mdpi.com
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability

K Li, J Guo, Y Ming, S Chen, T Zhang, H Ma… - Nature …, 2023 - nature.com
Metastasis is the leading cause of cancer-related death, where TGFβ-induced epithelial-
mesenchymal transition (EMT) process confers on cancer cells increased metastatic …

Podoplanin: an emerging cancer biomarker and therapeutic target

H Krishnan, J Rayes, T Miyashita, G Ishii… - Cancer …, 2018 - Wiley Online Library
Podoplanin (PDPN) is a transmembrane receptor glycoprotein that is upregulated on
transformed cells, cancer associated fibroblasts and inflammatory macrophages that …

Pyruvate kinase M2: A simple molecule with complex functions

M Alquraishi, DL Puckett, DS Alani, AS Humidat… - Free Radical Biology …, 2019 - Elsevier
Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under
different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last …

Evidence for Kaposi sarcoma originating from mesenchymal stem cell through KSHV-induced mesenchymal-to-endothelial transition

Y Li, C Zhong, D Liu, W Yu, W Chen, Y Wang, S Shi… - Cancer research, 2018 - AACR
The major transmission route for Kaposi sarcoma–associated herpesvirus (KSHV) infection
is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in …

Fibroblast-like synoviocytes-dependent effector molecules as a critical mediator for rheumatoid arthritis: current status and future directions

R Ganesan, M Rasool - International reviews of immunology, 2017 - Taylor & Francis
Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by
synovial hyperplasia and progressive destruction of joint. Currently available biological …

[HTML][HTML] Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation

P Carrasco-Ramírez, DW Greening, G Andrés… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Podoplanin (PDPN) is a transmembrane glycoprotein that plays crucial roles in embryonic
development, the immune response, and malignant progression. Here, we report that cells …

Near-infrared photoimmunotherapy targeting podoplanin-expressing cancer cells and cancer-associated fibroblasts

T Kato, A Furusawa, R Okada, F Inagaki… - Molecular cancer …, 2023 - AACR
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an
antibody-IRDye700DX (IR700) conjugate that binds to a target followed by the application of …