MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic …

Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …

One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

p21 cip1/waf1 mediates various biological activities by sensing and responding to multiple
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …

Introduction• Perlecan: a pro‐angiogenic proteoglycan• Endorepellin, a C‐terminal fragment
of perlecan with anti‐angiogenic activity• Syndecans in cancer biology• Glypicans and the …

Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been
widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show …

p21Waf1/Cip1/Sdi1 was originally identified as an inhibitor of cyclin-dependent kinases, a
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …

Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a
broad binding repertoire that encompasses matrix structural components, such as collagens …

Over the past decade, there has been much interest in the regulation of telomerase, the
enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in …