The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Liver metastases remain a major barrier to successful management of malignant disease,
particularly for cancers of the gastrointestinal tract but also for other malignancies, such as …

Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …

Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific
gatekeepers of their microenvironment. Microvascular ECs instruct neighboring cells in their …

Purpose Notch signaling dysregulation is implicated in the development of pancreatic
adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 …

For decades, cancer metastasis has been a heated topic for its high mortality. Previous
research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in …

Aberrant activation of the Notch signaling pathway is implicated in many solid tumors,
including hepatocellular carcinoma, indicating a potential use of Notch inhibitors for …

The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step
during metastatic progression. Notch signaling in organ-specific niches has been implicated …

Background The purpose of this study was to analyze the incidence and prognostic factors
of patients with breast cancer liver metastases (BCLM) at initial diagnosis. Methods We …

Background Neuroblastoma (NB) is the most common extracranial solid tumor of childhood,
and high-risk disease is resistant to intensive treatment. Histotripsy is a focused ultrasound …