The crystal structure of the dimeric membrane domain of human Band 3 1, the red cell
chloride/bicarbonate anion exchanger 1 (AE1, SLC4A1), provides a structural context for …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

SUMMARY Plasmalemmal Cl–/HCO3–exchangers are encoded by the SLC4 and SLC26
gene superfamilies, and function to regulate intracellular pH,[Cl–] and cell volume. The Cl …

The primary or hereditary forms of distal renal tubular acidosis (dRTA) have received
increased attention because of advances in the understanding of the molecular mechanism …

Plasmalemmal Cl−–HCO3− exchangers regulate intracellular pH and [Cl−] and cell volume.
In polarized epithelial cells, they contribute also to transepithelial secretion and reabsorption …

The family of mammalian bicarbonate transport proteins are involved in a wide-range of
physiological processes. The importance of bicarbonate transport follows from the …

The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-
secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+ …

Distal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic
acidosis with impaired urinary acid excretion in the presence of a normal or moderately …

Renal tubular acidosis is a metabolic acidosis due to impaired acid excretion by the kidney.
Hyperchloraemic acidosis with a normal anion gap and normal (or near normal) glomerular …

Mutations in the human gene that encodes the AE1 Cl−/HCO 3− exchanger (SLC4A1) cause
autosomal recessive and dominant forms of distal renal tubular acidosis (dRTA). A mouse …