CHARMM at 45: Enhancements in accessibility, functionality, and speed
Since its inception nearly a half century ago, CHARMM has been playing a central role in
computational biochemistry and biophysics. Commensurate with the developments in …
computational biochemistry and biophysics. Commensurate with the developments in …
Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
A key step in infections by enveloped viruses, such as influenza, is the fusion between the
viral envelope and the host cell membrane, which allows the virus to insert its genetic …
viral envelope and the host cell membrane, which allows the virus to insert its genetic …
Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection
HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion
peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion …
peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion …
Capturing spontaneous membrane insertion of the influenza virus hemagglutinin fusion peptide
JL Baylon, E Tajkhorshid - The Journal of Physical Chemistry B, 2015 - ACS Publications
Hemagglutinin (HA) is a protein located on the surface of the influenza virus that mediates
viral fusion to the host cellular membrane. During the fusion process the HA fusion peptide …
viral fusion to the host cellular membrane. During the fusion process the HA fusion peptide …
Self-assembly molecular dynamics simulations shed light into the interaction of the influenza fusion peptide with a membrane bilayer
Influenza virus is one of the most devastating human pathogens. In order to infect host cells,
this virus fuses its membrane with the host membrane in a process mediated by the …
this virus fuses its membrane with the host membrane in a process mediated by the …
Dynamic heterogeneous dielectric generalized born (DHDGB): an implicit membrane model with a dynamically varying bilayer thickness
An extension to the heterogeneous dielectric generalized Born (HDGB) implicit membrane
formalism is presented to allow dynamic membrane deformations in response to membrane …
formalism is presented to allow dynamic membrane deformations in response to membrane …
Closed and semiclosed interhelical structures in membrane vs closed and open structures in detergent for the Influenza Virus hemagglutinin fusion peptide and …
The∼ 25 N-terminal “HAfp” residues of the HA2 subunit of the influenza virus hemagglutinin
protein are critical for fusion between the viral and endosomal membranes at low pH. Earlier …
protein are critical for fusion between the viral and endosomal membranes at low pH. Earlier …
[PDF][PDF] Structural biology of the influenza virus fusion peptide
R Worch - Acta Biochimica Polonica, 2014 - bibliotekanauki.pl
The release of influenza RNA inside the host cell occurs through the fusion of two
membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by …
membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by …
Transferring the primo coarse-grained force field to the membrane environment: simulations of membrane proteins and helix–helix association
An extension of the recently developed PRIMO coarse-grained force field to membrane
environments, PRIMO-M, is described. The membrane environment is modeled with the …
environments, PRIMO-M, is described. The membrane environment is modeled with the …
Helical Hairpin Structure of Influenza Hemagglutinin Fusion Peptide Stabilized by Charge− Dipole Interactions between the N-Terminal Amino Group and the Second …
JL Lorieau, JM Louis, A Bax - Journal of the American Chemical …, 2011 - ACS Publications
The fusion domain of the influenza coat protein hemagglutinin HA2, bound to dodecyl
phosphocholine micelles, was recently shown to adopt a structure consisting of two …
phosphocholine micelles, was recently shown to adopt a structure consisting of two …