Computational biophysics meets cryo‐EM revolution in the search for the functional dynamics of biomolecular systems
There is a variety of experimental and computational techniques available to explore protein
dynamics, each presenting advantages and limitations. One promising experimental …
dynamics, each presenting advantages and limitations. One promising experimental …
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching
Protein synthesis is central to life and requires the ribosome, which catalyzes the stepwise
addition of amino acids to a polypeptide chain by undergoing a sequence of structural …
addition of amino acids to a polypeptide chain by undergoing a sequence of structural …
3D animation as a tool for integrative modeling of dynamic molecular mechanisms
M Riggi, RM Torrez, JH Iwasa - Structure, 2024 - cell.com
As the scientific community accumulates diverse data describing how molecular
mechanisms occur, creating and sharing visual models that integrate the richness of this …
mechanisms occur, creating and sharing visual models that integrate the richness of this …
[HTML][HTML] Imaging structurally dynamic ribosomes with cryogenic electron microscopy
SM Webster, MB May, BM Powell, JH Davis - ArXiv, 2023 - ncbi.nlm.nih.gov
Throughout the history of electron microscopy, ribosomes have served as an ideal subject
for imaging and technological development, which in turn has driven our understanding of …
for imaging and technological development, which in turn has driven our understanding of …
MDSPACE and MDTOMO Software for Extracting Continuous Conformational Landscapes from Datasets of Single Particle Images and Subtomograms Based on …
Cryo electron microscopy (cryo-EM) instrumentation allows obtaining 3D reconstruction of
the structure of biomolecular complexes in vitro (purified complexes studied by single …
the structure of biomolecular complexes in vitro (purified complexes studied by single …
Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from E. coli whole-genome sequences
Introduction: This work utilizes predictive modeling in drug discovery to unravel potential
candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we …
candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we …
Experimental and Computational Insights into Gangronema latifolium Leaf Compounds as GLP-1 Receptor Agonists
Abstract The International Diabetes Federation reported that in 2021, 6.7 million deaths
globally were linked to diabetes. Ethnomedicinal and scientific reports abound on using the …
globally were linked to diabetes. Ethnomedicinal and scientific reports abound on using the …
AFMfit: Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search
R Vuillemot, JL Pellequer, S Grudinin - bioRxiv, 2024 - biorxiv.org
Atomic Force Microscopy (AFM) offers a unique opportunity to study the conformational
dynamics of proteins in near-physiological conditions at the single-molecule level. However …
dynamics of proteins in near-physiological conditions at the single-molecule level. However …
23 Imaging Structurally Dynamic
JH Davis - Cryo-Electron Microscopy in Structural Biology: From …, 2024 - books.google.com
A HISTORY INTERTWINED and refinement of cryo-EM density maps, it also provides an
opportunity to see the full range of structural states populated in a sample. With the advent of …
opportunity to see the full range of structural states populated in a sample. With the advent of …
Molecular dynamics simulation based image analysis methods for structural studies of biological macromolecular complexesolecular complexes
R Vuillemot - 2023 - theses.hal.science
Cryo-Electron Microscopy (cryo-EM) allows conformational studies of macromolecular
complexes in their close-to-native state, essential for understanding their working …
complexes in their close-to-native state, essential for understanding their working …