Translational bioengineering strategies for peripheral nerve regeneration: opportunities, challenges, and novel concepts

KA Sarhane, C Qiu, TGW Harris… - Neural Regeneration …, 2023 - journals.lww.com
Peripheral nerve injuries remain a challenging problem in need of better treatment
strategies. Despite best efforts at surgical reconstruction and postoperative rehabilitation …

[HTML][HTML] IGF/IGF-1R signal pathway in pain: a promising therapeutic target

L Ma, W Zhao, S Huang, F Xu, Y Wang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Pain, one of the most important problems in the field of medicine and public health, has
great research significance. Opioids are still the main drugs to relieve pain now. However, its …

Ultrasound‐Responsive Composited Conductive Silk Conduits for Peripheral Nerve Regeneration

H Zhang, H Wang, B Wen, L Lu, Y Zhao… - Small Structures, 2023 - Wiley Online Library
Peripheral nerve injuries are challenging to repair clinically due to their limited regenerative
capacity. Herein, a novel poly (3, 4‐ethylenedioxythiophene): poly (4‐styrene …

Elastic porous microspheres/extracellular matrix hydrogel injectable composites releasing dual bio-factors enable tissue regeneration

Y Li, S Liu, J Zhang, Y Wang, H Lu, Y Zhang… - Nature …, 2024 - nature.com
Injectable biomaterials have garnered increasing attention for their potential and beneficial
applications in minimally invasive surgical procedures and tissue regeneration. Extracellular …

Electrospun PCL nerve conduit filled with GelMA gel for CNTF and IGF-1 delivery in promoting sciatic nerve regeneration in rat

H Xu, Z Gao, Z Wang, W Wu, H Li, Y Liu… - ACS Biomaterials …, 2023 - ACS Publications
Neural tissue engineering is an essential strategy to repair long-segment peripheral nerve
defects. Modification of the nerve conduit is an effective way to improve the local …

[HTML][HTML] Growth factors: Bioactive macromolecular drugs for peripheral nerve injury treatment–Molecular mechanisms and delivery platforms

T Wan, FS Zhang, MY Qin, HR Jiang, M Zhang… - Biomedicine & …, 2024 - Elsevier
Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and
Drug Administration (FDA), have found successful application in clinical practice. They hold …

Advancing our understanding of the chronically denervated schwann cell: a potential therapeutic target?

LA McMorrow, A Kosalko, D Robinson, A Saiani… - Biomolecules, 2022 - mdpi.com
Outcomes for patients following major peripheral nerve injury are extremely poor. Despite
advanced microsurgical techniques, the recovery of function is limited by an inherently slow …

Advances in large gap peripheral nerve injury repair and regeneration with bridging nerve guidance conduits

S Wu, W Shen, X Ge, F Ao, Y Zheng… - Macromolecular …, 2023 - Wiley Online Library
Peripheral nerve injury is a common complication of accidents and diseases. The traditional
autologous nerve graft approach remains the gold standard for the treatment of nerve …

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

J Fang, B Xu, X Jin, F Chen, S Liu, S Liu… - Macromolecular …, 2024 - Wiley Online Library
Peripheral nerve injuries (PNI) represent a prevalent and severe category of damage
resulting from traumatic incidents. Predominantly, the deficiency in nerve regeneration can …

Enhancing neuroinduction activity of PLCL-based nerve conduits through native epineurium integration

X Li, X Mao, M Tao, F Liang, X Tian, J Fan, X Wang… - Biomaterials …, 2024 - Elsevier
Autologous nerve grafts have been considered the gold standard for peripheral nerve grafts.
However, due to drawbacks such as functional loss in the donor area and a shortage of …