Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues
PA Hepburn, GP Margison, MJ Tisdale - Journal of biological chemistry, 1991 - ASBMB
The effect of O6-alkylation of guanine residues on the enzymic methylation of cytosine has
been studied using synthetic oligonucleotides in which all guanines in cytosine-guanine …
been studied using synthetic oligonucleotides in which all guanines in cytosine-guanine …
X-Ray Induction of O6-Alkylguanine-DNA Alkyltransferase Protects against Some of the Biological Effects of N-Methyl-N′-Nitro-N-Nitrosoguanidine in C3H 10T1 …
E von Hofe, AR Kennedy - Radiation research, 1991 - meridian.allenpress.com
We have shown previously that the repair of O6-methylguanine can be induced in murine
fibroblasts (C3H 10T1/2 cells) by exposure to X rays. The magnitude of the response is less …
fibroblasts (C3H 10T1/2 cells) by exposure to X rays. The magnitude of the response is less …
Inhibition of repair of O6-methyldeoxyguanosine and enhanced mutagenesis in rat-liver epithelial cells
NK Alvi, PG Foiles, GM Williams - Mutation Research/Fundamental and …, 1990 - Elsevier
The pro-mutagenicity of chemically-induced methylation of DNA at the O 6 position of
dexoyguanosine was studied in cultured adult rat liver epithelial cells. To modify the level of …
dexoyguanosine was studied in cultured adult rat liver epithelial cells. To modify the level of …
The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents
J Miyakoshi, DA Scudiero, J Allalunis-Turner… - Mutation Research/DNA …, 1991 - Elsevier
Abstract 4 repair-deficient (Mer−) and 2 repair-proficient (Mer+) lines of SV40-transformed
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
Individual genetic constellations as risk factors in chemical carcinogenesis
HW Rüdiger - Risk Assessment in Chemical Carcinogenesis, 1991 - Springer
Cancer can be considered to be a genetic disease for several reasons (Bouck and Benton
1989)—It results from stable, heritable changes in the cellular genome.—Almost all types of …
1989)—It results from stable, heritable changes in the cellular genome.—Almost all types of …
[引用][C] Role of 0 (6)-alkylguanine DNA alkyltransferase in the implementation of the antitumor activity of N-nitrosoureas (a review)
LB Gorbacheva, GV Kukushkina - Pharmaceutical Chemistry Journal, 1989 - Springer
N-Alkylnitrosoureas (ANU) are characterized by high antitumor activity, established on a
broad spectrum of experimental tumors in animals. Certain derivatives of ANU, such as l …
broad spectrum of experimental tumors in animals. Certain derivatives of ANU, such as l …